[The bioavailability of endogenous calcitonin under selective pharmacological sympathectomy]

The serum concentrations of calcitonin (CT) and sublemmal granule numerical density in the thyroid C-cell basal polus cytoplasm were measured in guanethidine-sympathectomized rats aged 2 weeks. Based on the previously proposed procedure [Krasnoperov et al. 1997], the confidence interval of endogenous CT bioavailability was found to be 52-100% (p > or = 0.95). It significantly differed from the similar control parameter (73-100%). The findings suggest that it cannot be excluded that unlike normal animals, sympathectomized 2-week rats may have CT retention at the transinterstitial and/or transmural stages of hemato-C-cellular mass-transfer.