Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transdermal nicotine suppresses cutaneous inflammation

C M Mills1, S A Hill, R Marks

  • 1Department of Dermatology, University Hospital of Wales, Cardiff.

Archives of Dermatology
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social Network Factors Affect Nutrition Risk in Middle-Aged and Older Adults: Results from the Canadian Longitudinal Study on Aging.

The journal of nutrition, health & aging·2023
Same author

Masseter muscle thickness as a predictive variable in treatment outcome of the twin-block appliance and masseteric thickness changes during treatment.

Orthodontics & craniofacial research·2010
Same author

Magnetic resonance imaging of the central nervous system.

IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society·2009
Same author

Allergic contact dermatitis complicating pustular psoriasis in two patients.

The British journal of dermatology·2007
Same author

Iatrogenic injury in childhood staphylococcal scalded skin syndrome.

Journal of paediatrics and child health·2003
Same author

Bilateral nail dystrophy associated with vibrating tool use.

The British journal of dermatology·2003

Transdermal nicotine patches reduced skin inflammation from irritants and UV-B in nonsmokers. This suggests nicotine partially explains smoking's anti-inflammatory effects on skin.

Area of Science:

  • Dermatology
  • Pharmacology
  • Inflammation Research

Background:

  • Cigarette smoking alters skin's inflammatory response to irritants.
  • The exact mechanism remains unclear, but nicotine is a potential factor.

Purpose of the Study:

  • To investigate the effect of transdermal nicotine on cutaneous inflammatory responses in humans.

Main Methods:

  • An interventional study involving 10 lifelong nonsmokers.
  • Participants applied nicotine patches daily for 1 month.
  • Skin tests included sodium lauryl sulfate, UV-B irradiation, and reactive hyperemia measurements.

Main Results:

  • Nicotine significantly reduced inflammatory responses to sodium lauryl sulfate and UV-B after 2 weeks.

Related Experiment Videos

  • A transient reduction in reactive hyperemia was observed.
  • No changes in blood flow were noted with topical nicotinates.

    • Conclusions:

    • Transdermal nicotine suppresses cutaneous inflammatory responses to irritants and UV-B.
    • Nicotine partially explains the anti-inflammatory effects associated with smoking.