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An unusual axonal polyneuropathy induced by low-dose interferon alfa-2a
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA.
Objectives:
To describe a patient who developed an unusual polyneuropathy after treatment with interferon alfa-2a for hepatitis C and to discuss issues related to diagnosis and pathogenesis.
Design:
Case report.
Setting:
Tertiary care center.
Case:
A 46-year-old man with chronic hepatitis C had acute onset of an axonal polyneuropathy with prominent small-fiber involvement shortly after completing a standard 6-month course of therapy with low-dose interferon alfa-2a.
Main Outcome And Results:
Further interferon treatment for hepatitis C was discontinued.
Conclusion:
Standard, low-dose interferon alfa-2a treatment can produce a persistent predominantly small-fiber polyneuropathy.