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Lymph node involvement by splenic marginal zone lymphoma: morphological and immunohistochemical features
M Mollejo1, E Lloret, J Menárguez
1Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain.
The American Journal of Surgical Pathology
|July 1, 1997
Summary
Splenic marginal zone lymphoma (SMZL) is a distinct low-grade B-cell lymphoma. Histological analysis of lymph nodes confirms SMZL
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Splenic marginal zone lymphoma (SMZL) is recognized as a distinct low-grade B-cell lymphoma.
- Differential diagnosis of SMZL from other lymphomas can be challenging.
- Histological patterns in lymph nodes affected by SMZL require further clarification.
Purpose of the Study:
- To investigate the histological and immunohistochemical features of splenic hilar and peripheral lymph nodes in SMZL.
- To compare these features with lymph nodes affected by other B-cell lymphomas.
- To confirm SMZL as a distinct clinicopathological entity.
Main Methods:
- Review of histological and immunohistochemical features of 19 lymph nodes from 14 SMZL cases.
- Comparison with lymph nodes from other B-cell lymphoma cases.
- Analysis of lymph node architecture, cellular morphology, and immunophenotype.
Main Results:
- Lymph node histology in SMZL mimics splenic white pulp, presenting a unique pattern.
- A nodular infiltrate effaces lymph node architecture, with preserved sinuses in some hilar nodes.
- Tumoral cells express IgD, IgM, and Ig light chain restriction with a low proliferation fraction.
Conclusions:
- SMZL exhibits a distinctive histological and immunohistochemical profile in lymph nodes.
- These findings support SMZL as a unique entity, not merely a pattern of other lymphomas.
- The study clarifies the lymph node manifestations of SMZL.