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Related Experiment Videos

Increased low-density lipoprotein peroxidation in elderly men

C Napoli1, P Abete, G Corso

  • 1Department of Clinical and Experimental Medicine, School of Medicine, Federico II University of Naples, Italy.

Coronary Artery Disease
|March 1, 1997
PubMed
Summary

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Low-density lipoprotein (LDL) peroxidation increases with age in men, with elderly men showing higher lipid peroxide levels and greater susceptibility to peroxidation. This age-related increase in LDL peroxidation may contribute to atherosclerosis progression in older populations.

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Lipid Metabolism

Background:

  • Oxidative modification of low-density lipoprotein (LDL) is implicated in atherogenesis.
  • The specific role of LDL peroxidation in the aging process remains unclear.
  • Estrogens may offer protection against LDL peroxidation, prompting an investigation focused solely on men.

Purpose of the Study:

  • To compare the susceptibility of LDL to peroxidation in healthy elderly men versus young and adult men.
  • To investigate age-related changes in LDL peroxidation markers.

Main Methods:

  • Isolated LDL from three groups of healthy men: young (19-23 years), adult (35-55 years), and elderly (77-90 years).
  • Exposed LDL to copper sulfate to induce peroxidation and evaluated lipid peroxidation markers.

Related Experiment Videos

  • Assessed vitamin E and arachidonic acid content within LDL.

    • Main Results:

    • Elderly men exhibited higher basal lipid peroxide levels in LDL compared to younger groups.
    • LDL from elderly men was more susceptible to peroxidation, with shorter lag times and increased lipid peroxide and malondialdehyde levels correlating with age.
    • Decreased vitamin E and increased arachidonic acid content were observed in LDL with aging, with vitamin E levels inversely correlating with peroxidation markers.

    Conclusions:

    • LDL peroxidation demonstrably increases with advancing age in men.
    • This age-associated increase in LDL peroxidation may promote the development and progression of atherosclerosis in elderly men.