Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating endothelin-1 in obstructive sleep apnea

S Saarelainen1, E Seppälä, K Laasonen

  • 1Department of Pulmonary Diseases, Tampere University Hospital, Pikonlinna, Finland.

Endothelium : Journal of Endothelial Cell Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay.

Microbiology spectrum·2023
Same author

Bactericidal efficiency of micro- and nanostructured surfaces: a critical perspective.

RSC advances·2022
Same author

Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

A novel discharge pathway for patients with advanced cancer requiring home parenteral nutrition.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2019
Same author

Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

A portable methane sampling system for radiocarbon-based bioportion measurements and environmental CH<sub>4</sub> sourcing studies.

The Review of scientific instruments·2017
Same journal

Melanoma Cell Invasive and Metastatic Potential Correlates with Endothelial Cell Reorganization and Tenascin Expression.

Endothelium : journal of endothelial cell research·2012
Same journal

31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel constructs as an enabling platform technology: II. The effect of anti-inflammatory drugs on phosphometabolite levels.

Endothelium : journal of endothelial cell research·2008
Same journal

31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: I. The effect of glial cells and valproic acid on phosphometabolite levels.

Endothelium : journal of endothelial cell research·2008
Same journal

p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.

Endothelium : journal of endothelial cell research·2008
Same journal

Interaction of estrogen and tumor necrosis factor alpha in endothelial cell migration and early stage of angiogenesis.

Endothelium : journal of endothelial cell research·2008
Same journal

Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro.

Endothelium : journal of endothelial cell research·2008
See all related articles

Endothelin-1 levels were elevated in men with obstructive sleep apnea, regardless of blood pressure. Continuous positive airway pressure treatment did not reduce these peptide levels.

Area of Science:

  • Cardiovascular Physiology
  • Sleep Medicine
  • Endocrinology

Background:

  • Endothelin (ET)-1 is a peptide with significant vasoconstrictive and mitogenic properties.
  • Endothelial cells produce ET-1, with primary degradation occurring in the pulmonary vasculature.
  • Elevated ET-1 is implicated in various cardiovascular conditions.

Purpose of the Study:

  • To investigate Endothelin-1 levels in men diagnosed with obstructive sleep apnea (OSA).
  • To compare ET-1 levels between normotensive and hypertensive OSA patients.
  • To assess the impact of continuous positive airway pressure (CPAP) treatment on ET-1 levels in OSA patients.

Main Methods:

  • Plasma Endothelin-1 concentrations were measured using immunoassays.
  • Participants included normotensive OSA patients, hypertensive OSA patients, and healthy controls.

Related Experiment Videos

  • Ten OSA patients were reassessed after three months of nCPAP therapy.

    • Main Results:

    • Endothelin-1 levels were significantly higher in both normotensive (6.3 +/- 2.8 pg/ml) and hypertensive (7.8 +/- 3.0 pg/ml) OSA groups compared to healthy controls (2.9 +/- 1.2 pg/ml).
    • No statistically significant difference was observed between normotensive and hypertensive OSA groups.
    • Following three months of nCPAP treatment, no significant reduction in Endothelin-1 levels was detected in the studied patients.

    Conclusions:

    • Obstructive sleep apnea is associated with elevated circulating Endothelin-1 levels.
    • Continuous positive airway pressure therapy may not effectively decrease Endothelin-1 in OSA patients.
    • Further research is warranted to explore the role of ET-1 in OSA pathophysiology and potential therapeutic targets.