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The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.
The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of offspring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%, respectively), and DNA values (50% and 34%, respectively) observed.