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Transient decrease of HPC-1/syntaxin-1A mRNA in the rat hippocampus by kainic acid
I Fujino1, T Fujiwara, K Akagawa
1Department of Physiology, Kyorin University School of Medicine, Tokyo, Japan.
Neuroscience Research
|July 1, 1997
Abstract:
HPC-1/syntaxin-1A is a neuronal protein of which the mRNA has an immediate early gene-like structure in its 3'-untranslated region. Whereas HPC-1/syntaxin-1A protein plays a crucial role in neurotransmitter release, little is known about HPC-1 gene expression. We demonstrate here that HPC-1 mRNA expression in rat hippocampal neurons in vivo decreased 8 h after kainic acid (KA) administration, but was restored thereafter. The transient decrease of HPC-1 mRNA upon KA administration suggests that the HPC-1 mRNA expression in neurons could be altered by excitation by trans-synaptic stimulation.