T-cell lymphocytic lymphoma involving the prostate presenting as elevated PSA in paraplegia: case report

The vast majority of cancers that involve the prostate are adenocarcinomas of the duct-acinar secretory epithelium. Other cancers, primarily leukemia and lymphoma, can involve the prostate and lead to an abnormal digital examination or elevated serum prostate specific antigen (PSA). The case discussed is that of a 62 year-old male with T12 complete paraplegia who presented with a persistently elevated PSA and was subsequently diagnosed with T-cell lymphoma involving the prostate. Although rare, leukemia and lymphoma involving the prostate should be included in the differential diagnosis of patients being evaluated for adenocarcinoma of the prostate.