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Related Experiment Videos

[Concomitant radiochemotherapy in invasive bladder tumors]

N Mottet1, M Di Palma, C Avances

  • 1Service d'urologie andrologie, CHU Doumergue, Nimes, France.

Bulletin Du Cancer
|April 1, 1997
PubMed
Summary

Combined radio-chemotherapy for muscle-invasive bladder cancer shows promising bladder preservation rates. However, further research is needed to define optimal protocols and long-term outcomes compared to radical cystectomy.

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[Brief history of BPH management].

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Area of Science:

  • Oncology
  • Urology

Context:

  • Muscle-invasive bladder tumors are typically treated with radical cystectomy and lymph node dissection.
  • Organ preservation strategies are being explored to improve patient quality of life.

Purpose:

  • To review the existing literature on combined radio-chemotherapy for muscle-invasive bladder cancer.
  • To evaluate the efficacy, safety, and bladder preservation rates of this treatment approach.

Summary:

  • A review of 9 studies (552 patients) found combined radio-chemotherapy for muscle-invasive bladder cancer yielded complete response rates of 48-92% and overall survival of 42-82%.
  • Bladder preservation survival ranged from 38-75%, with disease-free survival at 33-53%. Cisplatin was the most common agent, with generally good tolerance.
  • Recurrence rates were 11% for superficial and 30% for distant metastases.

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Impact:

  • Combined radio-chemotherapy offers a potential alternative to radical cystectomy, allowing for bladder preservation in select patients.
  • Lack of standardized protocols and the need for long-term functional data highlight the necessity for prospective randomized trials.
  • This approach may improve quality of life but requires careful patient selection and follow-up.