Update on recommendations for HIV postexposure prophylaxis

Using postexposure prophylaxis is likely to reduce the risk of infection from HIV exposure in health care workers, though data confirming this is limited. Initiation of therapy in a timely fashion with combination antiretroviral agents may be essential, but weighing risk of exposure to possible toxicity is also important. Careful follow-up including medication monitoring, HIV antibody testing, and supportive counseling are an integral part of PEP therapy. Identifying, ahead of time, key medical personnel to provide expertise in these issues could be helpful both in preventing delays, and in reducing fear and anxiety. Recommended medications should be available in emergency rooms and employee health clinics for this purpose.