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Liquid-phase combinatorial synthesis: in search of small-molecule enzyme mimics
A M Vandersteen1, H Han, K D Janda
1Scripps Research Institute, Department of Molecular Biology, Skaggs Institute of Chemical Biology, La Jolla, CA 92037, USA.
Molecular Diversity
|October 1, 1996
Abstract:
The applications, advantages and recent advances in liquid-phase combinatorial chemistry using poly-(ethyleneglycol) as a soluble polymer support are reviewed. Our recent efforts towards the synthesis of peptide-based catalysts on polyethyleneglycol are reported. The screening of libraries of peptides for catalysis is discussed.