Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA repair by oocytes

M J Ashwood-Smith1, R G Edwards

  • 1Biology Department, University of Victoria, Canada.

Molecular Human Reproduction
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Vertebrate oocytes can repair DNA damage from various sources. However, their repair capacity is reduced during specific meiotic stages, increasing sensitivity to genetic damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feminizing Adreno-Cortical Carcinoma: Report of a Case.

The Australian and New Zealand journal of surgery·2017
Same author

Detection of furocoumarins in plants and plant products with an ultrasensitive biological photoassay employing a DNA-repair-deficient bacterium.

Journal of chemical ecology·2013
Same author

Historical significance of gonadotrophins in assisted reproduction.

Reproductive biomedicine online·2013
Same author

Gonadotrophins--past, present and future.

Reproductive biomedicine online·2013
Same author

From embryonic stem cells to blastema and MRL mice.

Reproductive biomedicine online·2008
Same author

A burgeoning science of embryological genetics demands a modern ethics.

Reproductive biomedicine online·2007
Same journal

Small Molecule Ovastacin Inhibitors Preserve Fertilization Competence of Murine Eggs by Mimicking Fetuin-B Function.

Molecular human reproduction·2026
Same journal

Placental plasminogen activator inhibitor 1 is induced by platelet-derived TGF-β independently of TGF-β receptor 3 and is upregulated in preeclampsia.

Molecular human reproduction·2026
Same journal

Proceedings of the 1st European Ovary Workshop (EOW 2025) Lagos, Portugal - February 17-20, 2025.

Molecular human reproduction·2026
Same journal

How decidualization dysregulation reshapes the nanomechanics of endometrial stromal cells.

Molecular human reproduction·2026
Same journal

The post-reproductive ovary shifts from a reproductive to an immune-like organ.

Molecular human reproduction·2026
Same journal

Effects of changes in fat metabolism by particulate matter on endometrium and infertility.

Molecular human reproduction·2026
See all related articles

Area of Science:

  • Reproductive biology
  • Molecular genetics
  • Cell biology

Background:

  • Vertebrate oocytes possess DNA repair mechanisms to counteract damage.
  • DNA damage can arise from endogenous processes (e.g., meiotic recombination) and exogenous agents (e.g., UV, X-irradiation, chemicals).
  • The oocyte's sensitivity and repair capacity can vary throughout meiosis, particularly around the dictyate stage.

Purpose of the Study:

  • To review the DNA repair capabilities of vertebrate oocytes.
  • To highlight the reduced DNA repair capacity and increased sensitivity of oocytes at specific meiotic stages.
  • To emphasize the potential role of epigenetic factors in oocyte genetic integrity and repair.

Main Methods:

  • Review of experimental evidence from in vivo and in vitro systems.

Related Experiment Videos

  • Analysis of DNA damage and repair mechanisms in oocytes.
  • Consideration of factors affecting oocyte cytogenetic stability.

    • Main Results:

    • Oocytes demonstrate capacity for repairing various forms of DNA damage.
    • The dictyate stage of meiosis is characterized by reduced DNA repair capacity and heightened sensitivity to damaging agents.
    • Epigenetic factors influencing genetic fault expression in oocytes have been underappreciated.
    • Non-disjunctional events are common in dictyate oocytes.
    • Environmental factors like oxygen deprivation and temperature can disrupt microtubule structure, leading to cytogenetic damage.

    Conclusions:

    • Oocytes possess intrinsic DNA repair capabilities, but these are stage-dependent.
    • Understanding epigenetic factors is crucial for a comprehensive view of oocyte DNA repair.
    • The dictyate oocyte is vulnerable to non-disjunction and cytogenetic damage due to external factors.