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Influence of lactation on motor activity and elevated plus maze behavior
M R Silva1, M M Bernardi, A G Nasello
1Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de Sö Paulo, Brasil.
Summary
Lactation significantly alters rat behavior, reducing overall locomotion in open-field tests and decreasing exploration in the open arms of the elevated plus maze (EPM). These findings highlight how the physiological state of lactation influences anxiety-related behaviors.
Area of Science:
- Neuroscience
- Behavioral Endocrinology
- Animal Behavior
Background:
- Lactation is a significant physiological state impacting maternal behavior and neurobiology.
- Previous studies indicate altered responses to stress and anxiety in lactating rodents.
Purpose of the Study:
- To investigate the influence of lactation on anxiety-related behaviors in adult female rats.
- To assess behavioral changes in the open-field and elevated plus maze (EPM) during lactation.
Main Methods:
- Adult female rats in lactation and virgin controls were tested in an open-field and EPM.
- Locomotion (total and central) and rearing were recorded in the open-field.
- Entries and time spent in open/closed arms were measured in the EPM.
Main Results:
- Lactating rats showed significantly decreased total locomotion in the open-field compared to virgin rats.
- In the EPM, lactating rats spent significantly less time in the open arms and showed a trend towards fewer entries.
Conclusions:
- The physiological state of lactation significantly modulates anxiety-related behaviors in female rats.
- Lactation appears to induce behavioral changes reflected in reduced exploration and potentially increased anxiety in novel environments.