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Synthesis and antimycobacterial activity of nitroxanthones. 2nd communication: antimycobacterial activity
W G Ibrom1, K J Schaper, A W Frahm
1Department of Pharmacy, Faculty of Chemistry, University of Freiburg, Germany.
Arzneimittel-Forschung
|June 1, 1997
Abstract:
The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method. Nitroxanthones with the 2,4-dinitro-substitution pattern show activities beyond 1 microgram/ml.