Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action potential...
Normal Strain under Axial Loading01:20

Normal Strain under Axial Loading

Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
Generalized Hooke's Law01:22

Generalized Hooke's Law

The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
Eccentric Axial Loading in a Plane of Symmetry01:16

Eccentric Axial Loading in a Plane of Symmetry

Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Juxtarenal aortic aneurysms: preliminary experience with fenestrated E-vita abdominal stent-graft.

The Journal of cardiovascular surgery·2013
Same author

Predictors of response among patients with panic disorder treated with medications in a naturalistic follow-up: the role of adult separation anxiety.

Journal of affective disorders·2011
Same author

Double renal chimney graft using only femoral approach.

The Journal of cardiovascular surgery·2011
Same author

Does psychomotor retardation define a clinically relevant phenotype of unipolar depression?

Journal of affective disorders·2010
Same author

Clinical characteristics and treatment outcome of depression in patients with and without a history of emotional and physical abuse.

Journal of psychiatric research·2009
Same author

[Asbestos fibre lung burden and exposure indices in asbestos-cement workers].

La Medicina del lavoro·2009

Related Experiment Video

Updated: Jul 21, 2026

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

Pinching in longitudinal and alternate osteons during cyclic loading

A Ascenzi1, M G Ascenzi, A Benvenuti

  • 1Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy.

Journal of Biomechanics
|July 1, 1997
PubMed
Summary

Pinching in osteons, a material degradation, is caused by lesions like cracks or bond breakdown. Longitudinal osteons show more pinching than alternate ones due to fibril orientation and protection.

More Related Videos

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
05:03

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Related Experiment Videos

Last Updated: Jul 21, 2026

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
07:09

In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint

Published on: March 7, 2014

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
05:03

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Area of Science:

  • Materials Science
  • Biomechanics
  • Biomaterials Engineering

Background:

  • Pinching is a material degradation phenomenon observed under cyclic loading.
  • It is characterized by a change in the slope of the deflection curve, indicating lesions such as flexural cracks or bond degradation.
  • Understanding pinching is crucial for assessing the mechanical integrity of materials, especially biological tissues.

Purpose of the Study:

  • To investigate the phenomenon of pinching in fully calcified osteonic samples.
  • To compare the pinching behavior between longitudinal and alternate osteons under axial loading.
  • To analyze the stress-strain diagrams and energy absorption to understand the underlying mechanisms of pinching.

Main Methods:

  • Investigated 20 longitudinal and 18 alternate fully calcified osteon samples (500 micron length).
  • Applied axial loading beyond the proportional limit using an electromechanical device.
  • Utilized a microwave micrometer to measure length variations and a cubic polynomial model to analyze stress-strain diagrams.

Main Results:

  • The hysteretic behavior of longitudinal and alternate osteons differs significantly and deviates from ideal models.
  • Pinching in osteons is linked to the yielding of longitudinal fibrils, particularly incompletely calcified ones.
  • Longitudinal osteons exhibit magnified pinching lesions due to less protection from transverse fibrils, while alternate osteons show lessened lesions.

Conclusions:

  • The orientation and protection of collagen fibrils significantly influence pinching behavior in osteons.
  • Longitudinal osteons are more susceptible to pinching degradation compared to alternate osteons.
  • The findings provide insights into the mechanical failure mechanisms of bone and other fibrillar biomaterials.