Related Experiment Videos
[Synthesis of peptide and pseudo-peptide analogs of cholecystokinin]
1UA CNRS 492, Université de Reims, Champagne-Ardenne, Faculté de Pharmacie, Reims.
Annales Pharmaceutiques Francaises
|January 1, 1997
Abstract:
We describe selective CCKA receptor antagonists, based on the 1-oxo-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid core. Selectivity A vs B is discussed on the basis of molecular modelling. Chemical preparation uses electrophilic cyclization of isocyanates derivating from unnatural tryptophan esters. A stereoselective version of the reaction is given. A few peptides incorporating unnatural tryptophans are prepared, with a view of SAR.