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[Surface law and allometric analysis of functions]
1Departamento de Fisiología y Biofisica, Facultad de Medicina, Hospital Clinico de la Universidad de Chile, Santiago de Chile.
Revista Medica De Chile
|October 1, 1996
Summary
The surface law, used since 1883 for metabolic rates, may lead to errors when applied to other biological functions. This study introduces an allometric indexation procedure for mass-independent biological measurements.
Area of Science:
- Physiology
- Biophysics
- Allometry
Background:
- The "surface law", established in 1883, standardizes basal metabolic rate (kcal/24 h) per square meter of body surface.
- This law has been broadly applied to standardize cardiovascular, respiratory, and renal system functions.
- Extrapolation of the surface law may result in erroneous conclusions.
Purpose of the Study:
- To develop an allometric indexation procedure.
- To establish mass-independent numbers (MIN) for biological functions.
- To utilize dimensional analysis and biological similarity theories.
Main Methods:
- Dimensional analysis.
- Application of biological similarity theories.
- Development of an allometric indexation procedure.
Main Results:
- The proposed allometric indexation procedure yields mass-independent numbers (MIN).
- This method applies to functions definable within the MLT (Mass, Length, Time) system.
- Provides a novel approach to standardizing biological functions.
Conclusions:
- The allometric indexation procedure offers a more accurate method for standardizing biological functions than the surface law.
- This approach overcomes limitations associated with surface area standardization.
- Facilitates mass-independent comparisons across different biological scales.