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Systemic inflammatory response syndrome

M G Davies1, P O Hagen

  • 1Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

The British Journal of Surgery
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

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Systemic inflammatory response syndrome (SIRS) occurs when localized inflammation becomes uncontrolled, leading to exaggerated systemic reactions. Current research emphasizes the need for further study into SIRS and related conditions.

Area of Science:

  • Physiology
  • Pathology

Background:

  • Localized inflammation is a controlled physiological response to injury.
  • Uncontrolled inflammation can lead to Systemic Inflammatory Response Syndrome (SIRS).
  • SIRS involves a complex balance between the inflammatory response and compensatory mechanisms.

Purpose of the Study:

  • To review the current understanding of SIRS.
  • To examine the pathophysiology of SIRS.

Main Methods:

  • Literature review of SIRS.
  • Analysis of SIRS pathophysiology.

Main Results:

  • SIRS is characterized by an exaggerated systemic response to local injury.
  • The outcome of SIRS depends on the balance with compensatory mechanisms.

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  • Current therapies have not successfully influenced SIRS outcomes.

    • Conclusions:

    • Further research is needed to fully understand SIRS.
    • Investigating the natural history of SIRS and related syndromes is crucial.