Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic and essential metal interactions

R A Goyer

    Annual Review of Nutrition
    |January 1, 1997
    PubMed
    Summary
    This summary is machine-generated.

    Toxic metals like cadmium, lead, mercury, and aluminum can interfere with essential nutrients. Deficiencies in iron, calcium, and magnesium can worsen the toxic effects of these metals on the body.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals.

    Toxicological sciences : an official journal of the Society of Toxicology·2000
    Same author

    Prenatal care and infant lead exposure.

    The Journal of pediatrics·1997
    Same author

    Results of lead research: prenatal exposure and neurological consequences.

    Environmental health perspectives·1996
    Same author

    Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.

    The Journal of pharmacology and experimental therapeutics·1996
    Same author

    Renal tubular tumors and atypical hyperplasias in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy.

    Cancer research·1995
    Same author

    Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals.

    Environmental health perspectives·1995
    Same journal

    Mechanisms of NAD+ Homeostasis in Aging and Disease.

    Annual review of nutrition·2026
    Same journal

    Metabolite Damage and Repair in Health and Disease.

    Annual review of nutrition·2026
    Same journal

    From Food to Function: Cross-Kingdom Transfer and Regulatory Potential of Dietary microRNAs Highlighted by Breast Milk.

    Annual review of nutrition·2026
    Same journal

    The Influence of Diet on Cancer Progression and Treatment.

    Annual review of nutrition·2026
    Same journal

    The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.

    Annual review of nutrition·2026
    Same journal

    The Paradox and Future of GLP-1/GIP Combination Therapies: Efficacy and Mechanisms.

    Annual review of nutrition·2026
    See all related articles

    Area of Science:

    • Environmental toxicology
    • Nutritional biochemistry
    • Metabolic interactions of metals

    Background:

    • Toxic metals (cadmium, lead, mercury, aluminum) can disrupt essential mineral metabolism.
    • Nutritional status influences the absorption and toxicity of heavy metals.
    • Metabolic interactions between toxic and essential metals have significant health implications.

    Purpose of the Study:

    • To elucidate the metabolic interactions between toxic metals and essential nutrients.
    • To understand how nutritional deficiencies exacerbate heavy metal toxicity.
    • To highlight the impact of toxic metal exposure on physiological systems.

    Main Methods:

    • Literature review of studies on metal-metal and metal-nutrient interactions.
    • Analysis of biochemical pathways affected by toxic metal exposure.

    Related Experiment Videos

  • Examination of epidemiological data linking metal exposure and nutritional status.

    • Main Results:

    • Iron deficiency enhances the absorption of cadmium, lead, and aluminum.
    • Lead interferes with calcium in the nervous system, impairing cognitive function.
    • Cadmium and aluminum interact with calcium in bone, leading to osteodystrophies.
    • Lead and cadmium can displace zinc in vital enzymes and proteins.
    • Selenium mitigates mercury and methylmercury toxicity.
    • Aluminum's interaction with calcium affects bone and kidney health.
    • Calcium and magnesium deficiencies may contribute to aluminum-induced neurodegenerative diseases.

    Conclusions:

    • Toxic metals significantly interact with essential minerals, altering their metabolism and function.
    • Nutritional status plays a critical role in modulating the toxicity of heavy metals.
    • Understanding these interactions is crucial for preventing and managing metal toxicity and related health issues.