Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single-particle tracking: applications to membrane dynamics

M J Saxton1, K Jacobson

  • 1Institute of Theoretical Dynamics, University of California, Davis 95616, USA. mjsaxton@ucdavis.edu

Annual Review of Biophysics and Biomolecular Structure
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study.

Journal of Crohn's & colitis·2021
Same author

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network.

Journal of Crohn's & colitis·2019
Same author

Dietary patterns and risk of ulcerative colitis: a case-control study.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2018
Same author

The goblet cell-derived mediator RELM-β drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis.

Mucosal immunology·2016
Same author

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.

Genes and immunity·2015
Same author

Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance.

Gut microbes·2015
Same journal

Regulation of actin filament assembly by Arp2/3 complex and formins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Living with noisy genes: how cells function reliably with inherent variability in gene expression.

Annual review of biophysics and biomolecular structure·2007
Same journal

Physics of proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Fluorescence correlation spectroscopy: novel variations of an established technique.

Annual review of biophysics and biomolecular structure·2007
Same journal

Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

From "simple" DNA-protein interactions to the macromolecular machines of gene expression.

Annual review of biophysics and biomolecular structure·2007
See all related articles

Cell membrane proteins and lipids exhibit diverse movements beyond simple Brownian motion, including directed and confined paths. This complex cellular dynamics significantly impacts reaction rates and membrane understanding.

Area of Science:

  • Cell Biology
  • Biophysics
  • Membrane Dynamics

Background:

  • The plasma membrane is a dynamic environment crucial for cellular functions.
  • Understanding molecular motion within the membrane is key to deciphering cellular processes.

Purpose of the Study:

  • To characterize the diverse types of molecular motion in the cell plasma membrane.
  • To investigate the implications of non-Brownian motion on membrane-bound reactions and structure.

Main Methods:

  • Tracking individual protein and lipid trajectories within the plasma membrane.
  • Analyzing motion patterns to differentiate between Brownian and non-Brownian behaviors.

Main Results:

  • Observed Brownian motion for some membrane components.

Related Experiment Videos

  • Identified significant non-Brownian motion, including directed, confined, and anomalous diffusion.
  • Demonstrated that diverse motion types impact reaction kinetics.

    • Conclusions:

    • Cell membrane molecular motion is more complex than previously assumed.
    • Non-Brownian dynamics necessitate a re-evaluation of cell membrane structure and function.
    • These findings have implications for understanding cellular signaling and transport.