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Auditory event-related potentials and statistical probability mapping in obsessive-compulsive disorder

C M de Groot1, M W Torello, N N Boutros

  • 1Department of Psychiatric Medicine, East Carolina University, Greenville, North Carolina 27858-4354, USA.

Clinical EEG (Electroencephalography)
|July 1, 1997
PubMed
Summary

This study found altered auditory event related potentials (ERPs) in obsessive-compulsive disorder (OCD), suggesting cortical hyperarousal. Specific ERP changes correlated with symptom duration and severity in OCD patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Previous research suggests abnormalities in auditory event related potentials (ERPs) in obsessive-compulsive disorder (OCD).
  • Further investigation is needed to replicate and extend these findings, exploring correlations with symptom characteristics.

Purpose of the Study:

  • To replicate and extend previous findings on auditory ERPs in individuals with OCD.
  • To investigate the relationship between ERP characteristics and the chronicity and severity of OCD symptoms.

Main Methods:

  • Exploratory investigation comparing auditory ERPs in OCD subjects and healthy controls.
  • Analysis of specific ERP components including slow wave (SW) latency, P300 latency, and N200 amplitude.
  • Correlation analysis between ERP measures and OCD symptom chronicity and severity.

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Main Results:

  • OCD subjects exhibited decreased SW latency (post P300) and a trend towards decreased P300 latency compared to controls.
  • A greater N200 amplitude was observed in OCD subjects.
  • Chronicity of OCD symptoms correlated with the 140-170 ms integrated amplitude, and symptom severity correlated with the 386-438 ms integrated amplitude.

Conclusions:

  • Findings support the hypothesis that obsessive-compulsive disorder (OCD) involves, in part, cortical hyperarousal.
  • Specific auditory ERP alterations are linked to both the presence and characteristics of OCD symptoms.