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Related Experiment Videos

Bob was right

L B Holmes1

  • 1Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston 02114-2696, USA.

Reproductive Toxicology (Elmsford, N.Y.)
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Bob Brent pioneered methods to assess fetal harm from pregnancy exposures. His work clarifies when exposures are not teratogenic, providing a valuable scientific legacy.

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Area of Science:

  • Perinatology
  • Teratology
  • Reproductive Toxicology

Background:

  • Assessing pregnancy exposure risks is critical for fetal safety.
  • Determining non-teratogenicity is as important as identifying harmful effects.
  • Scientific debate on specific exposures like hormones and Bendectin highlights methodological challenges.

Purpose of the Study:

  • To highlight Bob Brent's contributions to evaluating pregnancy exposure safety.
  • To emphasize the importance of systematic methodology in teratology.
  • To acknowledge the legacy of Brent's research in reproductive toxicology.

Main Methods:

  • Systematic literature review and analysis of pregnancy exposures.
  • Development and application of criteria for assessing teratogenicity.

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  • Case studies illustrating the application of these methods.

    • Main Results:

    • Established a robust methodology for evaluating fetal effects of prenatal exposures.
    • Demonstrated the scientific rigor required to confirm non-teratogenicity.
    • Provided evidence-based assessments for controversial exposures.

    Conclusions:

    • Bob Brent's work provides a foundational methodology for assessing risks of exposures during pregnancy.
    • His research legacy is invaluable for future studies in teratology and reproductive safety.
    • The systematic approach is crucial for navigating complex scientific debates in the field.