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Related Experiment Videos

Plasminogen: an important hemostatic parameter in septic patients

C Duboscq1, I Quintana, E Bassilotta

  • 1Dpto. de Química Biológica, Facultad de Clencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.

Thrombosis and Haemostasis
|June 1, 1997
PubMed
Summary

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Low plasma plasminogen levels and the plasminogen to alpha-2-antiplasmin ratio are sensitive indicators of survival in sepsis patients. These markers can help predict patient outcomes in septicemia.

Area of Science:

  • Biochemistry
  • Hematology
  • Critical Care Medicine

Background:

  • Septic patients sometimes exhibit low plasma plasminogen concentrations.
  • This study investigates the prognostic value of plasminogen and related markers in sepsis.

Purpose of the Study:

  • To prospectively assess plasma plasminogen levels and the plasminogen/alpha-2-antiplasmin ratio as prognostic markers for sepsis survival.
  • To examine variations in other hemostatic parameters during septicemia.

Main Methods:

  • Prospective study involving 45 septic patients, 15 non-septic ICU patients, and 30 healthy volunteers.
  • Measurement of plasma plasminogen, alpha-2-antiplasmin, PAI-1, elastase-alpha-1-protease inhibitor, and thrombin-antithrombin complexes.
  • Western blot analysis to detect degraded plasminogen forms.

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Main Results:

  • Septic patients had significantly lower plasminogen concentrations than controls (p < 0.001).
  • Elevated levels of PAI-1, elastase-alpha-1-protease inhibitor, and thrombin-antithrombin complexes were observed in septic patients.
  • A 38 kDa degraded plasminogen form was detected in septic patients' plasma.
  • Plasminogen levels and the plasminogen/antiplasmin ratio demonstrated high sensitivity and specificity for predicting sepsis survival.

Conclusions:

  • Plasma plasminogen levels and the plasminogen/alpha-2-antiplasmin ratio serve as sensitive prognostic markers for survival in septicemia.
  • These markers can aid in evaluating patient prognosis during septic episodes.