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Acute myeloblastic leukemia associated with trisomy 8 and translocation 8;21 in a child with Down syndrome
Y Yamaguchi1, H Fujii, H Kazama
1Second Department of Pediatrics, Ohashi Hospital Toho University School of Medicine, Tokyo, Japan.
Cancer Genetics and Cytogenetics
|August 1, 1997
Abstract:
The present study examined an 11-year-old girl with Down syndrome who suffered from acute myeloblastic leukemia (AML) preceded by preleukemic pancytopenia. Chromosomal analysis of leukemic cells revealed a chromosome change at t(8;21) and trisomy 8 associated with constitutional trisomy 21. Treatment with antineoplastic agents led to complete remission.