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Updated: Aug 9, 2026

Measuring Physiological Responses of Drosophila Sensory Neurons to Lipid Pheromones Using Live Calcium Imaging
Published on: April 29, 2016
Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
K A Osborne1, A Robichon, E Burgess
1Department of Biology, York University, 4700 Keele Street, North York, Toronto, Ontario, Canada, M3J 1P3.
Abstract:
Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.
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