Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acyl-coenzyme A:cholesterol acyltransferase

T Y Chang¹, C C Chang, D Cheng

¹Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

Annual Review of Biochemistry

|January 1, 1997

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

cDNA sequence analysis and expression of the a chain of beta-bungarotoxin from Bungarus multicinctus (Taiwan banded krait).

Biochemical and biophysical research communications·1996

Same author

A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate.

Carcinogenesis·1996

Same author

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

The EMBO journal·1995

Same author

Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies.

The Journal of biological chemistry·1995

Same author

Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts.

The Journal of surgical research·1995

Same author

cDNA sequence analysis and expression of alpha-bungarotoxin from Taiwan banded krait (Bungarus multicinctus).

Biochemical and biophysical research communications·1995

Acyl-coenzyme A:cholesterol acyltransferase (ACAT) plays a key role in cholesterol balance. Understanding ACAT

Area of Science:

Biochemistry
Molecular Biology
Cellular Biology

Background:

Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is implicated in cellular cholesterol homeostasis.
ACAT's role in pathophysiological conditions has garnered significant research interest.

Purpose of the Study:

To review the pathophysiological roles of ACAT.
To discuss the biochemistry, molecular biology, and gene of ACAT.
To explore ACAT regulation by sterol and nonsterol agents.

Main Methods:

Review of existing literature on ACAT.
Analysis of ACAT gene and protein structure-function relationships.
Development of a model for ACAT's role in cholesterol trafficking.

Related Experiment Videos

Main Results:

Cloning the ACAT gene enables advanced molecular studies.
ACAT activity is regulated by sterol and nonsterol agents in mammalian cells.
A model is proposed linking ACAT's allosteric properties to endoplasmic reticulum cholesterol transport.

Conclusions:

ACAT is a critical enzyme for maintaining cellular cholesterol homeostasis.
Further research into ACAT's molecular mechanisms is warranted.
Understanding ACAT function is crucial for addressing related diseases.