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Viscosity measurements for LEH suspended in different plasma expanders
1Department of Biomedical Engineering, Chung-Yuan Christian University, Taiwan, R.O.C.
Summary
Liquid oxygen carriers (LEH) suspended in plasma expanders show potential for hemodilution. LEH/albumin suspensions (4-8%) offer optimal viscosity, suggesting value for further animal model testing.
Area of Science:
- Biomaterials Science
- Hemodynamics
- Fluid Mechanics
Background:
- Oxygen-carrying fluids are crucial for hemodilution strategies.
- Understanding the rheological properties of these fluids is essential for clinical application.
- Liquid hemoglobin (LEH) is a potential oxygen carrier, but its suspension properties need characterization.
Purpose of the Study:
- To evaluate the viscosity of liquid hemoglobin (LEH) suspensions in various plasma expanders.
- To determine the optimal plasma expander concentration for LEH-based hemodilution.
- To compare the rheological behavior of LEH suspensions with human blood.
Main Methods:
- Viscosity measurements of LEH suspended in different weight percentages of plasma expanders (albumin, dextran, oxypolygelatin).
- Testing across a range of shear rates to observe flow behavior.
- Comparison of suspension viscosity data against human blood viscosity at 40% hematocrit.
Main Results:
- All LEH/plasma expander suspensions exhibited shear-thinning behavior.
- Suspension viscosity increased with higher weight percentages of plasma expanders at fixed shear rates.
- LEH/albumin suspensions (4-8%) showed the most favorable viscosity, while LEH/dextran (6% Dex70c) was least favorable compared to human blood.
Conclusions:
- LEH/albumin and LEH/0.9% oxypolygelatin suspensions demonstrate promising viscosity profiles for hemodilution.
- Further efficacy testing in animal models is warranted for LEH/albumin and LEH/oxypolygelatin.
- Dextran-based suspensions are less suitable due to unfavorable viscosity.