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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
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Polyclonal staphylococcus endocarditis

E Van Wijngaerden1, W E Peetermans, S Van Lierde

  • 1Rega Institute, Catholic University of Leuven, Belgium.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 1, 1997
PubMed

Insights

Coagulase-negative staphylococcus (CNS) endocarditis can involve multiple distinct bacterial genotypes. This polyclonality, shown in a case of aortic homograft endocarditis, may impact treatment strategies and antibiotic susceptibility testing for prosthetic device infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Genomics

Background:

  • Coagulase-negative staphylococcus (CNS) is a leading cause of hospital-acquired infections, including bacteremia and prosthetic valve endocarditis.
  • While CNS bacteremia can be polyclonal, the clonality of CNS in endocarditis remains largely uncharacterized.
  • Prosthetic device infections caused by CNS share pathogenic similarities across various devices.

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