Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Substrate utilisation during exercise and shivering

M J Tipton1, G M Franks, G S Meneilly

  • 1Human and Applied Physiology Unit, Robens Institute, University of Surrey, Guildford, UK.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.

The journal of physiological sciences : JPS·2025
Same author

Development of a novel 'In-Water Mass Casualty Triage Tool'.

BMJ military health·2024
Same author

In at the deep end: the physiological challenges associated with artistic swimming.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2024
Same author

How to spot the truth.

Experimental physiology·2024
Same author

Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.

The journal of physiological sciences : JPS·2023
Same author

In pursuit of the unicorn.

Experimental physiology·2020

Exercise and shivering are not analogous in substrate utilization. Shivering increases plasma free fatty acids and beta-hydroxybutyrate, while exercise shows higher glucose output and utilization rates.

Area of Science:

  • Human Physiology
  • Metabolic Studies

Background:

  • Exercise is often modeled as a metabolic equivalent to shivering.
  • Substrate utilization differences between exercise and shivering remain unclear.

Purpose of the Study:

  • To compare substrate utilization during exercise and shivering at matched oxygen consumption (VO2).
  • To determine if exercise can serve as a valid model for shivering metabolism.

Main Methods:

  • Eight male subjects underwent 2-hour cold water immersion (shivering) and 2-hour bicycle ergometry (exercise).
  • Exercise intensity was adjusted to match VO2 levels recorded during shivering.
  • Measurements included hepatic glucose output (HGO), glucose utilization (Rd), blood glucose, plasma insulin, free fatty acid (FFA), and beta-hydroxybutyrate (B-HBA).

Related Experiment Videos

Main Results:

  • Hepatic glucose output and glucose utilization were significantly higher during exercise compared to shivering at the same VO2.
  • Plasma FFA and beta-hydroxybutyrate levels were elevated during shivering versus exercise.
  • Plasma insulin was higher during moderate shivering compared to exercise.

Conclusions:

  • Exercise and shivering are distinct metabolic processes regarding substrate utilization.
  • Exercise should not be used as a direct model for shivering metabolism, especially concerning fuel source differences.