Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dependence

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...

Drug-Receptor Interaction: Antagonist

Drug-Receptor Interaction: Antagonist

An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Phase I Reactions: Reductive Reactions

Phase I Reactions: Reductive Reactions

Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...

Pharmaceutical Poisoning: Treatment Strategies

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

Depressants

Depressants

Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nutrition and older adults.

Journal of gerontological nursing·2001

Same author

Nightingale's résumé. A student career-teaching strategy.

Nurse educator·2000

Same author

Mandatory reporting of abuse: practical, moral, and legal issues for psychiatric home healthcare nurses.

Issues in mental health nursing·2000

Same author

A chemical dependence clinical experience.

Nurse educator·1998

Same author

Protecting partial-hospitalization patients from suicide.

Perspectives in psychiatric care·1998

Same author

Research applications: domestic violence in the elderly.

Geriatric nursing (New York, N.Y.)·1998

Search research articles

Related Experiment Video

Updated: Jul 27, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

Naltrexone: a controversial therapy for alcohol dependence

P E Freed¹, L N York

¹Barnes College of Nursing, University of Missouri, St. Louis, USA.

Journal of Psychosocial Nursing and Mental Health Services

|July 1, 1997

Summary

Naltrexone hydrochloride (ReVia) can aid motivated patients with alcohol dependence. However, its use sparks controversy due to differing views on abstinence in treatment programs.

Area of Science:

Pharmacology
Addiction Medicine
Nursing Practice

Background:

Alcohol dependence is a significant public health issue.
Treatment for alcohol dependence often emphasizes complete abstinence.
Nurses play a crucial role in patient care and advocacy within addiction treatment.

Purpose of the Study:

To evaluate the efficacy of Naltrexone Hydrochloride (ReVia) as an adjunct treatment for alcohol dependence.
To explore the controversy surrounding Naltrexone therapy in the context of established treatment paradigms.
To inform nursing practice regarding patient advocacy and the application of nursing paradigms in addiction care.

Main Methods:

The study likely involved reviewing existing literature and clinical data on Naltrexone Hydrochloride (ReVia) for alcohol dependence.

More Related Videos

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Related Experiment Videos

Last Updated: Jul 27, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Analysis of patient outcomes in motivated individuals receiving Naltrexone as an adjunct therapy.

Examination of the philosophical and practical conflicts between Naltrexone therapy and abstinence-based models.

Main Results:

Naltrexone Hydrochloride (ReVia) shows potential as an effective adjunctive treatment for alcohol dependence in motivated patients.
The use of Naltrexone is contentious, contrasting with the abstinence-only approach favored by Alcoholics Anonymous and many medical programs.
Understanding this controversy empowers nurses to better advocate for patients and refine their care strategies.

Conclusions:

Naltrexone Hydrochloride (ReVia) offers a viable option for treating alcohol dependence, particularly for motivated individuals.
The controversy highlights the need for diverse treatment approaches in addiction medicine.
Nurses require knowledge of these controversies to effectively advocate for patient-centered care and integrate nursing theory.