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Synthesis and properties of [11-serine]alpha-melanotropin
Hoppe-Seyler'S Zeitschrift Fur Physiologische Chemie
|November 1, 1977
Abstract:
[Ser11]alpha-melanotropin has been prepared and its melanotropic activity compared with that of alpha-melanotropin and several known analogues. Full activity does not depend on the positive charge of 11-lysine in alpha-melanotropin but on the hydrophilic character of the amino group or a corresponding residue. A shift, or even more, a loss of such a group decreases the melanotropic activity.