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[Myopathy caused by inhibitors of hydroxymethylglutaryl-coenzyme A reductase]
F A Martinez-García1, J Martín-Fernández, J M Moltó
1Servicio de Neurologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Espana.
Introduction:
Hydroxymethylglutaryl-Coenzyme A (HMG-CoA) Reductase inhibitors are a group of drugs widely used for hypercholesterolemia. They are known to originate side-effects on muscles but with a very low incidence of myopathy.
Clinical Case:
We present two cases of myopathy induced by HMG-CoA reductase inhibitors. They are two women, who were on 20 mg daily of lovastatin and 30 mg daily of simvastatin and consulted due to weakness, myalgia and a rise in blood levels of muscle enzymes. Both of them recovered completely a few weeks after withdrawal of the drugs.
Comments:
Usage of this group of drugs is wide. Their side effects are rare but it is important to remember their capacity to induce a myopathy, usually reversible upon withdrawal of the drug.
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