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[Stroke therapy in children]
J Biller1, L S Williams, D K Sokol
1Departamento de Neurologia, Escuela de Medicina de la Universidad de Indiana, Indianapolis 46202-5124, USA.
Insights
Treatment for childhood cerebral infarction varied widely due to a lack of guidelines. Future research should focus on etiological basis for multicenter trials in pediatric stroke.
Area of Science:
- Pediatric Neurology
- Cerebrovascular Diseases
- Pediatric Stroke
Objective:
To evaluate the treatment modalities used in children (ages 1-18 years) with cerebral infarction.
Background:
[corrected] Cerebrovascular disease in children is more common than once suspected but its treatment has not been rigorously studied.
Material And Methods:
We reviewed all cases of cerebral infarction at the James Whitcomb Riley Hospital for Children at the Indiana University Medical Center from 01.01.80 to 31.12.95.
Results:
Ninety-three children who experienced ischemic strokes were followed over the past fifteen years. Fifty-seven males and thirty-six females comprised the sample. Mean age was 6.9 years at the time of stroke. No medication or surgical intervention was the therapeutic recommendation in 44% of patients. For cardioembolic strokes, warfarin was used later in the course for a few patients who went on to have atrial fibrillation or valve replacement. Aspirin was used in all patients with carotid artery dissections. Aspirin was used in most children with Moya-Moya, with calcium channel blockers and surgical intervention used in later cases. Exchange transfusion followed by monthly transfusion and chelation therapy has been the treatment of choice for children with cerebral infarction complicating sickle cell disease.
Conclusions:
In most instances, treatment was widely disparate, probably reflecting the lack of firm therapeutic guidelines for this age group, with a better understanding of the etiology and pathophysiology of strokes in children, multicenter, international, randomized therapeutic trials based strictly on an etiological basis should be organized in the future.