Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interferon therapy and autoimmunity]

J Fritzsch1, J Krug, H J Heberling

  • 1Stadtkrankenhaus, Leipzig.

Medizinische Klinik (Munich, Germany : 1983)
|May 15, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Passive artifact behavior prediction of interventional tools in high-field MRI using a 0.55T portable benchtop MR scanner.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2017
Same author

[Indications for catheter ablation of ventricular tachycardia].

Deutsche medizinische Wochenschrift (1946)·2013
Same author

Rounding effects in record statistics.

Physical review letters·2012
Same author

Correlations of record events as a test for heavy-tailed distributions.

Physical review letters·2012
Same author

[42-year-old patient with diarrhea since 6 months].

Deutsche medizinische Wochenschrift (1946)·2010
Same author

[Hyponatremia, rhabdomyolysis and encephalopathy after taking hydrochlorothiazide and drinking tea].

Deutsche medizinische Wochenschrift (1946)·2009

Interferon (IFN) therapy for viral hepatitis or cancers can trigger autoimmune diseases in about 3% of patients. Autoantibodies appear in 23%, with thyroid issues most common, necessitating careful monitoring during and after treatment.

Area of Science:

  • Immunology
  • Oncology
  • Hepatology

Context:

  • Interferon (IFN) therapy is a common treatment for viral hepatitis and various malignancies.
  • IFN treatment has been associated with an increased risk of developing autoimmune diseases.

Purpose:

  • To review the incidence and spectrum of autoimmune diseases associated with interferon therapy.
  • To discuss the potential pathogenetic mechanisms of IFN-induced autoimmunity.
  • To emphasize the need for clinical monitoring during and after IFN treatment.

Summary:

  • The incidence of overt autoimmune diseases during IFN treatment is approximately 3%, with autoantibodies detected in 23% of patients.
  • Autoimmune thyroid diseases are the most common, but a wide range of autoimmune conditions can manifest.

Related Experiment Videos

  • While some cases are benign and reversible, chronic or even fatal outcomes are possible.

    • Impact:

    • Highlights the significant risk of iatrogenic autoimmunity with IFN therapy.
    • Informs clinicians about the potential adverse effects, emphasizing the need for vigilant patient monitoring.
    • Contributes to understanding the complex interplay between cytokine therapy and immune system regulation.