[Neurotransmitter changes in multiple sclerosis]

Elevated levels of norepinephrine and of excitatory amino acids (glutamate, aspartate) were observed in cerebrospinal fluid of patients with multiple sclerosis while there were elevated content of glutamine, asparagine and glycine in their blood. An important point concerning these results was the relation between biochemical indices and the character of neurological symptoms, their severity as well as the course of the disease. The role of neurotransmitters in pathogenesis of multiple sclerosis and particularly in biochemical mechanisms of the relation between nervous and immune system that underlie the development of neurological deficiencies is suggested.