Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective IgG1 deficiency

C Lacombe1, P Aucouturier, J L Preud'homme

  • 1Laboratory of Immunology and Immunopathology, CNRS ESA 6031, Poitiers University Hospital, France.

Clinical Immunology and Immunopathology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing low laser damage densities of fused silica optics by means of a functional raster scan protocol.

The Review of scientific instruments·2023
Same author

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells.

Leukemia·2017
Same author

Anti-DNA antibodies by ELISA.

Immunology today·2014
Same author

Comment on "Evidence of a cascade and dissipation of solar-wind turbulence at the electron gyroscale".

Physical review letters·2013
Same author

Flow cytometric detection of dyserythropoiesis: a sensitive and powerful diagnostic tool for myelodysplastic syndromes.

Leukemia·2013
Same author

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

Leukemia·2013

Selective immunoglobulin G1 (IgG1) deficiency was identified in 119 adult patients, often linked to familial immunodeficiency and recurrent sinorespiratory infections. Asthma was notably prevalent in these patients.

Area of Science:

  • Immunology
  • Clinical Medicine
  • Genetics

Background:

  • Selective immunoglobulin G subclass deficiencies (IgGSD) are recognized immune disorders.
  • IgG1 deficiency, while less common than IgG2 deficiency, presents unique clinical and genetic associations.
  • Understanding the prevalence and clinical spectrum of IgG1 deficiency is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize the clinical and familial features of selective immunoglobulin G1 (IgG1) deficiency.
  • To investigate the association of IgG1 deficiency with other immunoglobulin levels and clinical manifestations.
  • To determine the frequency of infections and other comorbidities in patients with IgG1 deficiency.

Main Methods:

  • Serum levels of IgG subclasses (IgG1, IgG2, IgG3, IgG4), IgM, and IgA were measured in 3005 patients.

Related Experiment Videos

  • Patients with abnormally low IgG1 levels and normal other immunoglobulin levels were identified (n=119).
  • Clinical data, including infection history, familial immunodeficiency, and comorbidities, were analyzed.

    • Main Results:

    • 119 patients (predominantly adults) were diagnosed with selective IgG1 deficiency.
    • A familial context of immunodeficiency was frequent, with some cases showing IgG1 replacing IgG2 deficiency.
    • 83.2% of patients experienced moderate infections, primarily sinorespiratory. Asthma incidence was high (20%).

    Conclusions:

    • Selective IgG1 deficiency is a distinct entity within IgGSD, often familial, and associated with recurrent infections.
    • The high incidence of asthma in this cohort warrants further investigation.
    • Early identification and management of IgG1 deficiency are important for mitigating infectious complications and associated comorbidities.