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Related Experiment Videos

NMR relaxation studies with MnDPDP

T E Southon1, D Grant, A Bjørnerud

  • 1Nycomed Imaging AS, Oslo, Norway.

Acta Radiologica (Stockholm, Sweden : 1987)
|July 1, 1997
PubMed
Summary

Mangafodipir trisodium (MnDPDP) and manganese chloride (MnCl2) both enhance MRI relaxation rates. MnDPDP offers cardiovascular safety without sacrificing efficacy for T1-weighted imaging.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Imaging Agents
  • Pharmacology

Background:

  • Mangafodipir trisodium (MnDPDP) is a potential tissue-specific MRI contrast agent.
  • Manganese chloride (MnCl2) is a known MRI contrast agent.
  • Comparing the efficacy and optimal administration of MnDPDP versus MnCl2 is crucial for clinical application.

Purpose of the Study:

  • To compare the efficacy of MnDPDP as a tissue-specific MR agent against MnCl2.
  • To evaluate the impact of different doses and administration rates of MnDPDP.
  • To gather data for optimizing MRI pulse sequences with MnDPDP.

Main Methods:

  • Determined dose-response for R1 and R2 relaxation rates at 0.47 T for MnDPDP and MnCl2.
  • Measured manganese concentrations in rat liver and pig organs (liver, pancreas, heart, adrenals).

Related Experiment Videos

  • Utilized computer simulations to model effects of tissue Mn concentration and TR on signal intensity and contrast-to-noise ratios.

    • Main Results:

    • Both MnDPDP and MnCl2 showed a positive dose-response for R1 and tissue Mn concentration in rat liver and pig organs.
    • R2 relaxation rates showed minimal response to both agents.
    • Rat liver Mn concentration correlated positively with R1, irrespective of Mn form or administration rate.

    Conclusions:

    • MnDPDP provides cardiovascular safety over MnCl2 without compromising efficacy for increasing R1 at the clinical dose of 5 μmol/kg MnDPDP.
    • Minimal changes in R2 suggest limited impact on T2-weighted images.
    • The study provides a basis for selecting appropriate pulse sequences for MnDPDP-enhanced MRI.