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MnDPDP enhancement in rabbit liver after intravenous bolus injection and slow infusion
O Thorstensen1, B Isberg, H Jorulf
1Department of Diagnostic Radiology, University Hospital, Karolinska Institute, Huddinge, Sweden. ornthors@rhi.hi.is
Purpose:
To investigate the MR-enhancing effect of mangafodipir trisodium (MnDPDP, Teslascan) in the rabbit liver in relation to dose, mode of administration and imaging window.
Material And Methods:
MnDPDP was administered to 18 rabbits at a dose of 10 mumol/kg or 20 mumol/kg, as a bolus injection or infusion. MR imaging of the liver was performed at different time intervals.
Results:
Peak liver enhancement was typically observed 10-30 min after administration and the enhancement declined with a half-time of about 5 h. This pattern was observed in all sequences (SE 400/15, FLASH, and SE 132/10), with both doses and with both rates of administration. The peak enhancement was greater, though not significantly so after 20 mumol/kg than after 10 mumol/kg. A higher relative peak signal was observed with SE 132/10 than with FLASH or SE 400/15.
Conclusion:
A good liver imaging result was obtained after a dose of 10 mumol/kg, either bolus or infusion, 10-30 min post-contrast with heavily T1-weighted sequences.
Insights
Mangafodipir trisodium (MnDPDP) effectively enhances liver imaging in rabbits. Optimal results for liver MRI are achieved with a 10 mumol/kg dose, 10-30 minutes post-injection using T1-weighted sequences.
Area of Science:
- Radiology
- Medical Imaging
- Pharmacology
Background:
- Mangafodipir trisodium (MnDPDP) is a liver-specific contrast agent.
- Understanding its pharmacokinetic and pharmacodynamic properties is crucial for optimizing its use in Magnetic Resonance (MR) imaging.
Purpose of the Study:
- To evaluate the MR-enhancing effects of mangafodipir trisodium (MnDPDP) in rabbit livers.
- To determine the influence of dose, administration method (bolus vs. infusion), and imaging timing on liver enhancement.
Main Methods:
- Eighteen rabbits received MnDPDP at doses of 10 or 20 mumol/kg via bolus injection or infusion.
- Liver MR imaging was performed at various time points post-administration using different sequences (SE 400/15, FLASH, SE 132/10).
Main Results:
- Peak liver enhancement occurred 10-30 minutes after MnDPDP administration, with a half-life of approximately 5 hours.
- Both doses and administration methods yielded similar enhancement patterns across all tested MR sequences.
- A slightly higher peak enhancement was observed with the 20 mumol/kg dose, and the SE 132/10 sequence showed a higher relative peak signal.
Conclusions:
- A dose of 10 mumol/kg of MnDPDP, administered either as a bolus or infusion, provides good liver imaging results.
- Optimal imaging is achieved 10-30 minutes post-contrast using heavily T1-weighted sequences.