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Effect of endoscopic sphincterotomy on gallbladder motility
D K Agarwal1, B C Sharma, R K Dhiman
1Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Digestive Diseases and Sciences
|July 1, 1997
Summary
Endoscopic sphincterotomy (ES) improves gallbladder emptying in humans with gallstones. This procedure enhances gallbladder motility, reducing both resting and stimulated volumes, and increasing ejection fraction.
Area of Science:
- Gastroenterology
- Hepatobiliary Medicine
- Medical Imaging
Background:
- Sphincterotomy in animals aids gallbladder emptying and prevents gallstones.
- Gallbladder emptying post-endoscopic sphincterotomy (ES) in human gallstone patients remains understudied.
Purpose of the Study:
- To prospectively evaluate the effect of ES on gallbladder motility in humans with choledocholithiasis and an in-situ gallbladder.
Main Methods:
- Real-time ultrasonography was used to measure gallbladder volumes (resting and cerulein-stimulated) before and after ES in 15 patients.
- Patients included those with and without gallbladder calculi.
Main Results:
- ES significantly reduced resting gallbladder volume (21.2 to 11.1 mL) and stimulated residual volume (10.8 to 4.4 mL).
- Gallbladder ejection fraction significantly increased post-ES (47.3% to 58.8%).
- The rate constant for gallbladder emptying significantly increased after ES (-0.022/min to -0.031/min).
Conclusions:
- Endoscopic sphincterotomy significantly improves gallbladder motility in human patients.
- Enhanced gallbladder emptying was observed in both patients with and without gallstones.