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Ovarian cysts and cyclic hormone replacement therapy: is there an association?
I Bar-Hava1, R Orvieto, D Vardimon
1Department of Obstetrics and Gynecology, Rabin Medical Center (Golda Campus), Petah-Tiqva, Israel.
Objectives:
To evaluate whether there may be an association between postmenopausal ovarian cysts and hormone replacement therapy.
Methods:
The study comprised 564 consecutive, asymptomatic, postmenopausal women who were referred for routine, transvaginal ultrasound examinations between January 1 and December 31, 1995. Various demographic and ultrasonographic parameters were recorded on a prospectively-created, computerized data base.
Results:
There was no difference in the prevalence of ovarian cysts with or without hormone replacement therapy (10.5% vs. 12.5%, respectively). However, in the subgroup of early postmenopausal women (40-55 years), the use of hormone replacement therapy was associated with a significantly reduced prevalence of ovarian cysts (10.4% vs. 28.6%; p < 0.05).
Conclusions:
Hormone replacement therapy is associated with a reduced prevalence of ovarian cysts in early postmenopause.