Using structure to define the function of phosphoinositide 3-kinase family members

FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.

Oncogene·2005

Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.

British journal of cancer·2004

Factors governing the solubilization of phosphopeptides retained on ferric NTA IMAC beads and their analysis by MALDI TOFMS.

Journal of the American Society for Mass Spectrometry·2002

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

Annual review of cell and developmental biology·2001

Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.

Molecular and cellular biology·2001

Proteomics--post-genomic cartography to understand gene function.

Trends in pharmacological sciences·2001

Partial depletion of plasminogen activator inhibitor-1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high-fat-fed female mice.

FEBS letters·2026

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

FEBS letters·2026

The impact of aging on the gut-liver axis in health and disease.

FEBS letters·2026

Autophagy and mitophagy in pancreatic β-cell homeostasis and their involvement in diabetes pathophysiology.

FEBS letters·2026

Oxidative modification of the D1 residue 332H during photoinactivation drives photosystem II turnover.

FEBS letters·2026

Synergistic perspectives-How single-molecule biophysics complement biochemical understanding.

FEBS letters·2026

Leveraging network pharmacology in the treatment of asthma.

ADMET & DMPK·2026

Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study.

ADMET & DMPK·2026

Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors.

ADMET & DMPK·2026

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Journal of medicinal chemistry·2026

Four Novel Quassinoid Skeletons from Brucea mollis via Guided Separation and Biomimetic Synthesis.

Organic letters·2026

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus.

Current microbiology·2026

Related Experiment Videos

Using structure to define the function of phosphoinositide 3-kinase family members

Related Concept Videos

FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.

Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.

Factors governing the solubilization of phosphopeptides retained on ferric NTA IMAC beads and their analysis by MALDI TOFMS.

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.

Proteomics--post-genomic cartography to understand gene function.

Partial depletion of plasminogen activator inhibitor-1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high-fat-fed female mice.

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

The impact of aging on the gut-liver axis in health and disease.

Autophagy and mitophagy in pancreatic β-cell homeostasis and their involvement in diabetes pathophysiology.

Oxidative modification of the D1 residue 332H during photoinactivation drives photosystem II turnover.

Synergistic perspectives-How single-molecule biophysics complement biochemical understanding.

Leveraging network pharmacology in the treatment of asthma.

Cholinesterases inhibition profiles with Ugi-derived peptidemimetics: A combined experimental and computational study.

Structure-activity relationship of captopril derivatives as New Delhi metallo beta-lactamase 1 inhibitors.

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Four Novel Quassinoid Skeletons from Brucea mollis via Guided Separation and Biomimetic Synthesis.

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus.

Related Experiment Videos

Using structure to define the function of phosphoinositide 3-kinase family members

Related Concept Videos

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