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Related Experiment Videos

Alimentary tract malignancies in children

C A Bethel1, N Bhattacharyya, C Hutchinson

  • 1Department of Surgery, The Children's Hospital The Ohio State University, Columbus 43205-2696, USA.

Journal of Pediatric Surgery
|July 1, 1997
PubMed
Summary

Pediatric intestinal malignancies are rare, with non-Hodgkin

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Area of Science:

  • Pediatric Oncology
  • Gastrointestinal Surgery
  • Hematology/Oncology

Background:

  • Alimentary tract malignancies in children are uncommon.
  • This study reviews surgical cases of intestinal malignancy in pediatric patients.

Purpose of the Study:

  • To analyze the types, primary sites, and outcomes of pediatric intestinal malignancies.
  • To identify trends in the incidence of specific lymphoma subtypes over time.

Main Methods:

  • Retrospective review of 55 surgical cases of intestinal malignancy in children from 1952 to 1996.
  • Analysis of tumor types, locations, patient demographics, and survival data.

Main Results:

  • Non-Hodgkin's lymphomas constituted 75% of cases, predominantly in the colon and small bowel.
  • A significant increase in small bowel lymphoma, particularly Burkitt's lymphoma, was observed after 1982.
  • Localized disease and complete resection were favorable prognostic factors for lymphoma survival.

Conclusions:

  • Lymphoma is the most frequent pediatric intestinal malignancy, with Burkitt's lymphoma emerging as a significant entity.
  • Trends indicate a shift towards Burkitt's lymphoma in pediatric intestinal malignancies.
  • Complete surgical resection is crucial for improving survival in pediatric intestinal lymphomas.

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