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Preliminary experience with intrasphincteric botulinum toxin for persistent constipation after pull-through for
1Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
Journal of Pediatric Surgery
|July 1, 1997
Summary
Botulinum toxin injections offer a less invasive alternative for treating persistent constipation in children after Hirschsprung
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Neuromuscular Disorders
Background:
- Hirschsprung's disease surgery can lead to persistent constipation due to internal sphincter achalasia.
- Anal myectomy is a treatment option but causes permanent sphincter injury and is not always effective.
- Botulinum toxin is a safe agent for reversibly weakening muscles and sphincters.