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Trivalent chromium and the diabetes prevention program

L A Linday1

  • 1College of Physicians and Surgeons, New York, NY, USA.

Medical Hypotheses
|July 1, 1997
PubMed
Summary

The Diabetes Prevention Program investigates lifestyle changes and medications to prevent type 2 diabetes. Trivalent chromium, a cost-effective supplement, could also reduce insulin resistance but was omitted.

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Area of Science:

  • Endocrinology
  • Preventive Medicine
  • Metabolic Disorders

Background:

  • Impaired glucose tolerance is a precursor to non-insulin-dependent diabetes mellitus.
  • Insulin resistance is a key factor in the development of impaired glucose tolerance.
  • The Diabetes Prevention Program is a large-scale NIH-funded study.

Purpose of the Study:

  • To determine if non-insulin-dependent diabetes mellitus can be prevented or delayed.
  • To evaluate the efficacy of lifestyle interventions and specific medications.
  • To assess the role of insulin resistance in diabetes development.

Main Methods:

  • Random assignment of 4000 subjects to four groups: lifestyle intervention, metformin, troglitazone, or control.
  • Follow-up duration of 4.5 years.
  • Standardized diet and exercise protocols for intervention and control groups.

Main Results:

  • The study aims to compare the effectiveness of different interventions in preventing or delaying diabetes.
  • Analysis will focus on the incidence of non-insulin-dependent diabetes mellitus across study groups.
  • The role of insulin resistance in treatment outcomes will be examined.

Conclusions:

  • The Diabetes Prevention Program provides valuable data on diabetes prevention strategies.
  • Trivalent chromium, a supplement that potentiates insulin action, was not included in the study.
  • The omission of trivalent chromium, a cost-effective option for reducing insulin resistance, is noted as unfortunate.

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