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Effects of midazolam on pain sensations in the face
O Nakanishi1, Y Amano, T Ishikawa
1Department of Dental Anesthesiology, Kyushu Dental College, Kitakyushu, Japan.
Objectives:
This study investigated the effects of midazolam, a sedative, on tactile and pain sensations on the skin of the chin.
Study Design:
Thirty-seven volunteers were segregated into four groups; the first group was the control group; the second to fourth groups were administered 0.025 mg/kg, 0.05 mg/kg, and 0.075 mg/kg of midazolam, respectively, as a bolus injection. All volunteers reclined in a dental chair for the experiment. Tactile and pain sensations were determined over time after injection of midazolam, the former using von Fray thread, the latter using an esthesiometer.
Results:
Thresholds of tactile sensitivity and of pain were statistically significantly different from control values at 10 minutes after injection of midazolam in the 0.05 mg/kg group and in the 0.075 mg/kg group.
Conclusion:
Although 0.025 mg/kg of midazolam produced sedation, at least 0.05 mg/kg of this agent was required to alter the thresholds for perception of tactile and painful stimulation.