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Updated: Aug 9, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

The prohost effect of antimicrobial agents as a predictor of clinical outcome

M T Labro1

  • 1INSERM U294, Service d'Hématologie et d'Immunologie Biologiques, CHU Xavier BICHAT, Paris, France.

Journal of Chemotherapy (Florence, Italy)
|May 1, 1997
PubMed

Insights

Antimicrobial agents can impact infections beyond killing microbes. They may alter bacterial virulence, influence host immune responses, and affect immune cell development, potentially changing disease outcomes.

Area of Science:

  • Microbiology
  • Immunology
  • Pharmacology

Background:

  • Antimicrobial agents possess direct antimicrobial activity.
  • These agents can also modulate host-pathogen interactions.
  • This modulation affects the natural host response to pathogens.

Purpose of the Study:

  • To review the non-antibiotic effects of antimicrobial agents.
  • To explore how these agents interfere with host-microorganism interplay.
  • To assess the clinical relevance of these effects.

Main Methods:

  • Review of literature on antimicrobial agent non-antibiotic effects.
  • Analysis of mechanisms modulating bacterial virulence.
  • Examination of interactions with host immune responses.
  • Investigation of effects on immune cell progenitors.

Main Results:

  • Antimicrobial agents can alter bacterial virulence factors.
  • They may enhance or inhibit the natural host immune response.
  • Effects on immune cell progenitors can impact overall immunity.
  • These non-antibiotic actions can influence infectious disease outcomes.

Conclusions:

  • The non-antibiotic effects of antimicrobial agents are significant.
  • Modulation of bacterial virulence and host response are key aspects.
  • Impact on immune cell progenitors warrants further investigation.
  • These effects have potential clinical implications for infectious diseases.

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