Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

COX-1 and COX-2 tissue expression: implications and predictions

L J Crofford1

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0531, USA.

The Journal of Rheumatology. Supplement
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unstimulated inflammatory activity is associated with treatment response to cognitive-behavioral therapy for urologic chronic pelvic pain.

Frontiers in pain research (Lausanne, Switzerland)·2025
Same author

Real-world electronic health record identifies antimalarial underprescribing in patients with lupus nephritis.

Lupus·2019
Same author

Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus.

Lupus·2018
Same author

Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration.

Prostaglandins, leukotrienes, and essential fatty acids·2010
Same author

Polymyositis evolving after rhabdomyolysis associated with HMG-CoA reductase inhibitors: a report of two cases.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2006
Same author

Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia.

Arthritis and rheumatism·2005

Cyclooxygenase-1 (COX-1) is a housekeeping gene for homeostasis, while cyclooxygenase-2 (COX-2) is induced during inflammation and implicated in diseases like arthritis and cancer. Selective COX-2 inhibitors may offer anti-inflammatory benefits with reduced toxicity.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Cyclooxygenase-1 (COX-1) functions as a housekeeping gene, maintaining physiological processes like gastric mucosal integrity and renal blood flow.
  • Cyclooxygenase-2 (COX-2) is an inducible gene, upregulated during inflammation and implicated in conditions such as rheumatoid arthritis.
  • Differential expression and regulation of COX-1 and COX-2 suggest distinct physiological roles.

Purpose of the Study:

  • To elucidate the distinct functions of COX-1 and COX-2 based on their tissue expression and regulation.
  • To explore the role of COX-2 in inflammatory processes and certain cancers.
  • To predict the therapeutic potential of selective COX-2 inhibitors.

Main Methods:

  • Review of existing literature on COX-1 and COX-2 expression and function.

Related Experiment Videos

  • Analysis of COX-2 upregulation in inflammatory conditions (e.g., rheumatoid arthritis) and cancer.
  • In vitro studies examining COX-2 induction by proinflammatory cytokines (IL-1, TNF-alpha).

    • Main Results:

    • COX-1 is constitutively expressed, supporting homeostatic functions.
    • COX-2 expression is tightly regulated and dramatically upregulated during inflammation, notably in rheumatoid arthritis synovial tissues.
    • COX-2 is also elevated in certain cancers, potentially linked to apoptosis resistance.

    Conclusions:

    • The distinct expression patterns of COX-1 and COX-2 support their different physiological roles.
    • Upregulated COX-2 contributes to pathological processes involving increased prostaglandin production.
    • Selective COX-2 inhibitors are predicted to offer effective anti-inflammatory activity with potentially reduced toxicity compared to non-selective agents.