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The nicotine inhaler in smoking cessation
A Hjalmarson1, F Nilsson, L Sjöström
1Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Göteborg, Sweden.
Archives of Internal Medicine
|August 11, 1997
Summary
The nicotine inhaler is an effective smoking cessation aid, improving success rates compared to placebo. This nicotine replacement therapy option offers a new way to quit smoking with mild side effects.
Area of Science:
- Pharmacology
- Addiction Medicine
- Public Health
Background:
- Nicotine replacement therapy (NRT) improves smoking cessation success.
- Existing NRTs can cause adverse effects, limiting use.
- A novel nicotine inhaler delivers nicotine orally via inhalation, mimicking smoking behavior.
Purpose of the Study:
- To evaluate the efficacy and safety of a nicotine inhaler for smoking cessation.
- To compare the nicotine inhaler's effectiveness against a placebo.
Main Methods:
- A 1-year, randomized, double-blind, placebo-controlled trial.
- 247 smokers (≥10 cigarettes/day, prior NRT attempts) were recruited.
- Participants used either a nicotine inhaler or placebo inhaler for 6 months.
Main Results:
- Higher continuous abstinence rates at 12 months for nicotine inhaler users (28%) vs. placebo (18%; P=.046).
- More nicotine inhaler users (16%) continued use at 6 months compared to placebo (3%; P<.001).
Conclusions:
- The nicotine inhaler is an effective aid for smoking cessation.
- This NRT method demonstrated mild and transient adverse effects.