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08:13
Preparation of Murine Submandibular Salivary Gland for Upright Intravital Microscopy
Published on: May 7, 2018
Submandibular glands: novel structures participating in thermoregulatory responses
R D Mathison1, T Malkinson, K E Cooper
1Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, AB, Canada.
Canadian Journal of Physiology and Pharmacology
|May 1, 1997
Summary
Submandibular glands modulate endotoxin-induced fever, with their removal enhancing the late-phase fever response. A peptide from these glands, submandibular gland peptide-T (SGP-T), suppressed this enhanced fever.
Area of Science:
- Immunology
- Physiology
- Endocrinology
Background:
- Submandibular glands influence cardiovascular and immunological responses.
- Their role in regulating endotoxin-induced fever is not well understood.
Purpose of the Study:
- To investigate the role of submandibular glands in modulating endotoxin-induced fever.
- To examine the effect of submandibular gland peptide-T (SGP-T) on fever responses.
Main Methods:
- Core body temperature was measured in rats via telemetry.
- Rats underwent either sialadenectomy (submandibular gland removal) or sham operation.
- Fever was induced by intraperitoneal injection of Escherichia coli endotoxin.
- Rats were treated with SGP-T before endotoxin administration.
Main Results:
- Sialadenectomized rats exhibited a significantly higher second phase of fever compared to sham-operated rats.
- SGP-T treatment suppressed the late-phase fever response in a dose-dependent manner.
- Daytime body temperature was lower in sialadenectomized rats, but circadian variation remained.
Conclusions:
- Submandibular glands play a significant role in modulating thermogenic responses to inflammatory stimuli.
- Submandibular gland peptide-T (SGP-T) may be involved in the endocrine regulation of fever.
- These findings suggest a potential therapeutic target for inflammatory conditions.
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